Cardiothoracic Surgery

Faculty Publications

The Department of Cardiothoracic Surgery is dedicated to the principles of vision, perseverance, and rigorous scientific investigation in its commitment to conducting well-conceived, cutting-edge research. The department generates dozens of peer-reviewed journal publications annually in its efforts to maintain its respected status among cardiothoracic research groups worldwide.

Featured Publications

Presystolic mitral annular septal-lateral shortening is independent from left atrial and left ventricular contraction during acute volume depletion.

Bothe W, Nguyen TC, Roberts ME, Timek TA, Itoh A, Ingels NB Jr, Miller DC.

Excerpt: The mitral annulus (MA) is a dynamic structure that joins the left atrium (LA) and left ventricle (LV), but it is unknown whether MA motion is coupled to the LA or the LV or neither of the two. Since a well orchestrated coordination of LA, MA and LV septal-lateral (S-L) dynamics is essential for efficient valve closure, we assessed their functional coupling in an experimental ovine model. More »

Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart.

van der Bogt KE, Schrepfer S, Yu J, Sheikh AY, Hoyt G, Govaert JA, Velotta JB, Contag CH, Robbins RC, Wu JC.

Excerpt: Mesenchymal stem cells hold promise for cardiovascular regenerative therapy. Derivation of these cells from the adipose tissue might be easier compared with bone marrow. However, the in vivo fate and function of adipose stromal cells (ASC) in the infarcted heart has never been compared directly to bone marrow-derived mesenchymal cells (MSC). This is the first study comparing the in vivo behavior of both cell types in the infarcted heart.
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